Effect of triclabendazole on the tegument of schistosoma mansoni: a scanning electron microscopic study

The in vitro effect of triclabendazole on the tegument of Schistosoma mansoni was studied by means of scanning microscopy. Two different concentrations of drug were used [15 mug/ml and 75 mug/ml] and the worms examined after different exposure times [1 hour, 3 hours, 24 hours]. It was found that exposure of S. mansoni to triclabendazole resulted in quick reactions. The tegument was immediately destroyed after exposure in several places, leading to the formation of defects in the surface of the worms. The parasites contracted and became immobilized within one hour, showing that the uptake of the drug was very rapid and triclabendazole caused 100% mortality after 24 hours in the 2 concentrations. The ultrastructural changes were proportional to the concentration of drug and time elapsed

Prevention of human fascioliasis: a study of the role of acids detergents and potassium permanganate in clearing salads from metacercariae

Prevention of human fascioliasis could depend on clearing the leafy salads from the metacercariae. The present work evaluated the role of some chemicals in detaching and killing this infective stage. It was observed that washing in running water for 10 minutes detached only 50% of the metacercariae. Citric acid in the concentration of [10 ml/L], commercial vinegar [120 ml/L], liquid soap [12 ml/L] and KMnO4 [24 mg/L] detached all metacercariae after 10 minutes exposure. The use of vinegar and KMnO4 was recommended; the former is lethal to other parasites in the vegetables, the second destroyed the metacercariae. Vegetable leaves were not softened and remained fresh