Residue-concentration of malathion and its metabolites in blood, urine, milk and tissues of lactating goats after multiple oral administration

Determination of Residues of Malathion [M] and its metabolic fractions Malaoxon [MO], 0, O-dimethyl-phosphoro dithionate [DPDT], Malathion mono acid [MCA], Dicarboxylic acid [DCA] and desmethylmalathion [DMM], in serum, urine and tissues of lactating goats received a daily dose [10mg-1 kg] body weight of [M] for 5 successive days was investigated. Daily samples of blood and urine were collected during the period of administration as well as 7 and 14 days after withholding of [M]. Tissue samples were taken from slaughtered goats at 7 and 14 days after cessation of the insecticide. Gas chromatographic technique [GC] was adopted for determination of [M] and its metabolites. [M] was not detected in any serum samples collected during administration and/or after cessation of insecticide, while it was excreted unchanged in urine and milk till one week after cessation of treatment with neurotoxic concentration over 20 ng/ml. The active metabolites [MO] and [DPDT] were not detected in any milk samples collected during application or after stoppage of [M] administration, while both metabolites were detected in serum and urine with neurotoxic concentrations during period of administration and still detected in serum for 7 days [400 ng/ml] and DPDT for 14 days [241 ng/ml] after stopping of [M] administration. The major excretory detoxified metabolites was found in milk on the days 7 and 14 after cessation of Malathion. Tissue residue-analysis

Role of urethral wall components in the continence mechanism

An experimental model is used to test the role of the components of the urethral wall and its elasticity in the continence mechanism. The model consists of [1] a modified plastic syringe with three openings; one on each end and the third on its upper surface [2] a condom, a double condom and a double condom with K - Y jelly in between acting as a urethra