Histopathological study of the effects of ethamsylate [dicynone] on rabbit's eye

The effects of intacameral injection of 0.3 ml of dicynone on ocular tissues of rabbits were studied. Progressive atrophic changes affecting the cornea, iris, ciliary body and the optic nerve of rabbits' eyes were observed. The details of these atrophic changes were discussed. There was also a lowering of the intra-ocular pressure of the rabbits' eyes after dicynone Injection into their anterior chamber

Histochemical changes in pregnant rat's liver following repeated halothane exposure [1]

Eighteen adult white rats were divided into 3 groups, 6 rats each, 2 males. The first group was exposed to 1.5% halothane for 20 minutes, every other day, for 6 exposures. The rats mated and exposed for another 10 exposures. The second group was given 0. 1% phenobarbitone in milk, one week before and during the period of exposure, which similar to the first group. The third group was kept as a control. At the suspected date of delivery, the rats weresacrified and specimens were taken from the mother's liver for estimation of the activities of the enzymes succinate dehydrogenase, acid phosphatase and alkaline phosphatase. Repeated halothane exposure decreased the activity of the enzymes succinate dehydrogenase, acid phosphatase and alkaline phosphatase. Treatment with phenobarbitone has the same effect on succinate dehydrogenase, but partially spared the activities of acid and alkaline phosphatases

Histopathological changes in pregnant rat's liver following repeated halothane exposure [2]

Adulte white rats were divided into 3 groups, 6 rats each [2 and 4]. The first group was exposed to 1.5% halothane for 20 minutes every other day for 6 exposures. The rats were mated and exposed another 10 exposures. The second group was given 0.1% phenobarbitone in milk one week before, and during the period of exposure which was similar to the first group. The third group was kept as a control. At the suspected date of delivery, the rats were sacrified, and specimens were taken from the liver for haematoxylin and eosin stain, PAS reaction and Sudan black stain. Repeated exposure to halothane did not affect the pregnancy rate, but it resulted in hepatic focal and centrilobular necrosis with glycogen poverty and moderate lipid content. The portal spaces showed thick connective tissue and lymphocytic infiltration. Phenobarbitone reduced the pregnancy rate and resulted in 16.5% foetal mortality with more hepatic necrosis and increases in glycogen and lipid content