effect of lormetazepam and midazolam on some monoamines and amino acid levels in the brains of guinea pigs

The effect of lormetazepam and midazolam on norepinephrine, dopamine, gamma-amino-butyric acid [GABA], L-glutamic acid and their enzymes were investigated in both acute and chronic experiments. A significant decrease in the levels of norepinephrine and dopamine was observed in midazolam group in acute and chronic studies, while an insignificant change was observed with lormetazepam. Both drugs caused a significant increase in GABA and glutamic acid decarboxylase in L-glutamic acid and gamma-aminobutyric alpha ketoglutaric transaminase activity [GABA-T]