RESUMEN
The purpose of this study was to investigate the effect of concurrent training on serum paraoxonase-1 [PON1] activity and lipoprotein profile in the blood of obese women. Twenty-four non-active exercise healthy women volunteered to participate in this research. They were randomly assigned into two groups: concurrent exercise group [n=12] and control group [n=12]. Duration of training was 4 weeks, 3 sessions per week and each session lasted for 55-70 minutes. Concurrent exercise group carried out exercises at 60-80 percent of maximal reserve heart rate. Dependent variables were measured in the two phases of the study, including pre-test and post-test. Findings of the present study show significant increase in PON1 activity [P=0.01], however, lipid indexes of this research including LDL [P=0.414], HDL [P=0.22], VLDL [0.159], CH [P=0.1566] were not significantly changed. On the other hand, blood TG concentration was significantly reduced [P=0.001]. In addition, in obese women without exercise activity, level of paraoxonase1 has a significant relationship with HDL [P=0.02], but no relation was observed with the other lipid indexes of this research [P<0.05]. The result of this study showed that after four weeks of concurrent training, increased enzyme paraoxonase 1 and decreased TG concentration were observed. But it seems the PON1 enzyme in inactive obese women has a significant relationship with HDL lipid parameters and other factors were not related to research. Thus, this protocol can be employed in inactive exercise obese men with inhibits the oxidation of LDL and limiting the HDL in circulation of blood with the goal of effectively prevent cardiovascular disease. Finally, in active people, exercise can increase PON1 induced enhanced in the total antioxidant system of the body