Evaluation of ethanolic extract of Moringa oleifera for wound healing, anti-inflammatory and antioxidant activities on rats

The present study deals with evaluation of continuous heat extracted fraction of Moringa oleifera leaves for antioxidant, wound healing and anti-inflammatory activities in albino Wistar rats. The antioxidant activity was carried out by conventional DPPH radical scavenging method, wound healing activity was performed by considering incision, excision, dead space wound model followed by histopathological studies and anti-inflammatory activity was carried out by using carageenan-induced rat paw oedema method. The wounds treated with experimental extract shows faster wound closure [24-27 days] and epithelization as compared to wound under untreated group [more than 30 days]. The different diluted extract shows antioxidant activity in range of 16.24% to 32.78%. The extract shows significant anti-inflammatory activity as compared to standard reference drug Ibuprofen. The result revealed that the anti-inflammatory activity possibly attributes to its free radical scavenging activity

Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form

Fixed dose combination tablets containing ambroxol HCI and cetirizine HCI are clinically used as mucolytic and antiallergic. Several spectrophotometric and HPLC methods have been reported for simultaneous estimation of these drugs with other drugs. The drugs individually and in mixture obeys Beer's law over conc. range 1.2-4.4 micro g/mL for cetirizine HCL and for ambroxol HCL 15-52 micro g/mL at all five sampling wavelengths [correlation coeff. Well above 0.995]. The mean recoveries from tablet by standard addition method were 100.18% [ +/- 2.4] and 100.66% [ +/- 2.31]. The present work reports simple, accurate and precise spectrophotometric methods for their simultaneous estimation from tablet dosage form