Thermodynamic dissociation constant studies of caffeine at different temperatures and in organic water solvent mixture

Thermodynamic dissociation studies have been carried out potentiometrically at various temperatures from 25 to 50oC and in 10, 20, 30 and 40% v/v dioxane-water solvent mixture at 25oC. The influence of temperature and nature of solvent on dissociation equilibria of caffeine is being investigated A computer program in GW-BASIC has been used to calculate the pK values