Portubations of amino acid levels in plasma and liver of rat by cadmium chloride

1. Plasma and liver free amino acid concentrations were measured in Sprague Dawley rats before and after acute cadmium exposure. 2. In plasma threonine, valine and argenine were decreased. While citrulline was highly elevated after Cd administration. On the other hand, hepatic cysteine, methionine, glutamic acid and glycine were lower in Cd treated group than in control one. Other Quantified plasmaa and liver free amino acids were clearly unaffected. 3. Interpretations for the abnormalities in plasma and liver free amino acid concentrations were discussed in detail

Changes in metal contents in toad tissues after manganese loading

The effect of manganese [0.03, 0.30 or 3.00 mg Mn[+2]/Kg], administered subcutaneously to male toads for three months, on mineral dispositions [Mn, Ca, Fe, Cu Mg, Zn, and inorganic phosphate] in blood, liver and kidney were examined. After this time of exposure, significant increases in Mn levels in the three tissues were observed. While Ca and Fe contents were reduced in the blood, liver and kidney, Ca content was increased only in the blood and reduced in the others. No alterations were found in other parameters

Carbon tetrachloride poisoning: physiological and biochemical observations

The effectiveness of carbon tetrachloride [CC1[4]] on serum and liver enzyme activities as well as total serum bilirubin, cholesterol and triglyceride levels were investigated in the Egyptian toad after a single S.C. dose of 2.8 ml/kg. At 24 h. exposure period all the selected enzymes were stimulated in the serum, while the liver enzymes varied in their sensitivities to this toxicant. Total serum bilirubin was increased, while cholesterol and triglyceride levels were reduced

Dose-response effects of various metal ions on the lethality of carbon tetrachloride

Several attempts were made to determine the effective concentrations of metal ions that can protect toads from a lethal dose of carbon tetrachloride [5.066 ml CC[4]/kg]which represents 24 hr LD 100]. The most preferable concentrations were: 728.000, 168.108, 2.080, 1120.550, 180.196, 15.471 and 2.208 micro mol/kg. for manganese, cobalt, selenium, zinc, calcium, lead and mercury, respectively