Effects of medication with ivermectin, chloroquine and artemether on plasma nitrate / nitrite levels in calves naturally infected with onchocerca gutturosa

In a comparative study involving the use of Ivermectin, Chloroquine and Artemether against Onchocerca gutturosa in calves, the plasma nitrate /nitrite concentration was measured. Following treatment and clearance of skin mf of O. gutturosa, the plasma nitrate/ nitrite concentrations, nor the stable end product of Nitric Oxide [NO] breakdown, rise significantly although it showed short peaks following reduction in dermal mf counts but no clear correlation was detected