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1.
An. acad. bras. ciênc ; 89(1,supl): 373-382, May. 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-886653

RESUMEN

ABSTRACT Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as starting material to make chemical transformation leading to saturated cardanol, epoxides and, halohydrins. These derivatives were tested for toxicity against Aedes aegypti larvae. The results showed that iodohydrins are very promising compounds for making commercial products to combat the vector mosquito larvae presenting a LC50 of 0.0023 ppm after 72 h of exposure.


Asunto(s)
Animales , Fenoles/farmacología , Aedes/efectos de los fármacos , Insecticidas/farmacología , Fenoles/aislamiento & purificación , Fenoles/toxicidad , Fenoles/química , Factores de Tiempo , Insecticidas/síntesis química , Insecticidas/toxicidad , Larva/efectos de los fármacos , Dosificación Letal Mediana
2.
An. acad. bras. ciênc ; 89(3,supl): 2273-2280, 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-886818

RESUMEN

ABSTRACT Control strategies using insecticides are sometimes ineffective due to the resistance of the insect vectors.In this scenario new products must be proposed for the control of insect vectors.The complexes L-aspartate Cu (II) and L-glutamate-Cu (II) complexes were synthesized and characterized by elemental analysis, visible ultraviolet, infrared spectroscopy and potentiometric titration. The toxicity of these complexes was analyzed in Aedes aegypti (Diptera: Culicidae) larvae and Gram-negative and Gram-positive bacteria. The interaction between the ligands and the amino acid balance and the distribution of the species as a function of pH were discussed. The lethal concentration median (LC50) for Ae. aegypti larvae were: L-glutamic acid-Cu (II) - 53.401 mg L-1 and L-aspartate-Cu (II) - 108.647 mg L-1. The minimum inhibitory concentration (MIC) required for Staphylococcus aureus and Escherichia coli was: L-glutamate-Cu (II) 500-2000 mg L-1 and L-aspartate-Cu (II) 1000-2000 mg L-1. The concentrations demonstrated toxicity that evidence the potential of the complexes as bactericide and insecticide. Metal complexes formed by amino acids and transition metals are advantageous because of low environmental toxicity, biodegradability and low production cost.


Asunto(s)
Animales , Staphylococcus aureus/efectos de los fármacos , Ácido Aspártico/química , Ácido Glutámico/química , Cobre/química , Aedes/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Pruebas de Toxicidad , Larva/efectos de los fármacos , Dosificación Letal Mediana
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