RESUMEN
Lamivudine is approved for clinical use and used widely in treatment of Hepatitis Band AIDS either alone or in combination with another antiviral drugs because of its watersolubility and shorter half-life (5-7 hrs) drug requires frequent dosing by oral route, off variousrecent techniques for controlling drug release, matrix system offer various advantages of easeof formulation better control on release profile of drug and better patient compliance. Thematrix tablets formulation by direct compression method is most acceptable in large scaleproduction. It is concluded that formulation of sustained release tablet of Lamivudinecontaining 80 mg of hydroxypropyl-methylcellulose E15 (high viscosity grade) and 80 mg ofethylcellulose i.e. formulation F7 can be taken as an ideal or optimized formulation ofsustained release tablets for 16 hours release as it fulfills all the requirements for sustainedrelease tablet and our study encourages for the further clinical trials and long term stabilitystudy on this formulation.
RESUMEN
About 40% of the drug candidates have poor water solubility due to their low bioavailability. Self-emulsifying drug delivery systems (SEDDs) are mixtures of oils, surfactants and co-surfactants, which efficiently improve dissolution and bioavalabilty of sparingly soluble drugs by rapid self-emulsification. SEDDs belongs to lipid formulations, and size ranges from 100nm (SEDDs) to less than 50nm (SMEDDs). Lipophilic drugs can be dissolved in such systems, enabling them to be administered as a unit dosage form for per-oral administration. When such system is released in the lumen of the gastrointestinal tract, it disperses to form a micro/nano emulsion with the aid of GI fluid. These leads to solubilisation of drug that can subsequently be absorbed by lymphatic pathways, by passing the hepatic first pass effect.