Biochemical responses to level-1 Yo-Yo intermittent recovery test in young Tunisian football players

The aim of this work was to investigate the metabolic and muscle damage responses after the level-1 Yo-Yo intermittent recovery test [YYIRT] in young football players. Fifteen male football players [17.42 +/- 0.2 yrs, 69.91 +/- 4.4 kg, 178.64 +/- 3.8 cm; mean +/- SD] participated in this study. Fasting blood samples for various biochemical parameters [i.e. lactate [Lac], glucose [GLC], triglycerides [Tri], creatine kinase [CK], uric acid [UA]] collected from a forearm vein after 5-min of seated rest and 3-min after the test. Moreover, rating of perceived exertion [RPE] and maximal heart rate during and after the YYIRT were recorded. Mean levels of the selected biochemical markers were raised after the YYIRT exercise [P<0.001 for the other markers]. Moreover, lipid parameters increased significantly after the test [P<0.01 for Tri and P<0.001 for HDL]. These findings confirm the higher metabolic demand of aerobic as well as anaerobic metabolism and reflect a significant mobilization of purine cycle during the YYIRT. The increase of muscle damage markers also reflects the higher anaerobic solicitation. From these findings, we can conclude the importance of aerobic and anaerobic metabolism during soccer-specific endurance performance [i.e. YYIRT, soccer match]

[Association between oxidative stress parameters and inflammations markers according to the gravityt of the acute coronary syndrome]

Cardiovascular disease is the consequence of appearance and development of atherosclerosis lesions of associated with a inflammatory complication. To elucidate a possible association between several inflammation and oxidative stress markers according to the severity of coronary artery disease. This study was carried on 93 coronary subjects with: unstable angina [UA; n=42]; stable angina [SA; n=15] and acute myocardial infarction [AMI; n=36] and 140 control subjects to whom lipidic, oxidative and inflammatory parameters were determined. In addition to a moderate hyperhomocysteinemia observed in the coronary artery disease, a significant higher levels of the oxidized LDL [ox-LDL] were found among these patients [p< 0.001]. A positive correlation was found between the markers of the inflammation and the gravity of the acute coronary syndrome. One note a significant increase of the rate of ox-LDL and high sensitive CRP to AMI by reports in UA and SA [p=0.00, and p=0.001 respectively] which is linked to an elevation of the plasmatic concentration of the total homocysteine. This study suggests an association between the markers of the inflammation and oxidative parameters in the acute coronary syndrome