RESUMEN
Polycystic ovary syndrome [PCOS] is the most common endocrinopa-thy in women. It may involve an impairment in physiologic regulation of leptin and ghrelin. There is limited, controversial data on the relation of dietary components with leptin and ghrelin in PCOS, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and ghrelin in PCOS and healthy subjects. In this case-control study, we randomly choose 30 PCOS patients and 30 healthy age and body mass index [BMI] matched controls. Intake of macro-nutrients [protein, total fat, saturated, monounsaturated and polyunsaturated fatty acids [PUFA], carbohydrate, dietary fiber] and energy were assessed using 3-day, 24-hour food recall and food frequency questionnaires [FFQ]. Fasting hormonal status was measured for each participant. PCOS women had higher levels of serum leptin, insulin, testosterone, and lute-inizing hormone [LH], whereas sex hormone-binding globulin [SHBG] was lower compared to healthy women. There was no significant difference in mean ghrelin concentrations between the groups. Among PCOS women, independent of BMI and total energy intake, we observed an inverse association between leptin concentration and total dietary fat [p=-0.16, P<0.05] and saturated fatty acid [SFA] intake [p=-0.58, P<0.05]. This relationship was not seen in the healthy subjects. There was no significant association between ghrelin and macronutrients in PCOS and healthy participants. Certain habitual dietary components such as fat and SFA may decrease serum leptin, whereas ghrelin is not influenced by these in PCOS women. More studies are needed to better clarify the effects of dietary macronutrients on serum leptin and ghrelin