DNA content of pathological thyroid tissue in different thyroid diseases

DNA of pathological and normal thyroid tissue was extracted and estimated according to Burton. Thyroid carcinoma had DNA content significantly higher than follicular adenoma, Grave's disease, non toxic nodular goitre and normal thyroid. Moreover each type of carcinoma has different DNA content from the other types. Follicular adenoma had significantly higher DNA content than Grave's disease, non toxic nodular goitre and normal thyroid. Three suspecious borderline cases were categorised in the carcinoma group because of their high carcinoma like DNA values. Accordingly DNA estimation could be an aid in the diagnostic problems of thyroid tumors