RESUMEN
Targeting epidermal growth factor receptors [EGFR] is an innovative approach to managing non-small cell lung cancer [NSCLC] which harbors EGFR mutation. However, the efficacy of these agents like erlotinib in patients without the mutation is not known. This systematic review included Phase III randomized clinical trials that compared single agent erlotinib to other management options in the setting of NSCLC with reported outcome data on patients with EGFR wild type [EGFRWT] tumors. Outcome data include overall survival [OS], progression free survival [PFS] and response rate [RR]. Random effects meta-analysis was used to pool outcomes across studies. Three studies met the inclusion criteria. These studies included a total of 2044 patients with outcome data on 674 patients with EGFRWT tumors [33%]. Meta-analysis revealed a statistically significant improvement in OS with erlotinib [hazard ratio of 0.780; 95% confidence interval: 0.654-0.930, P = 0.006]. Data were not available to perform PFS or RR analysis. The quality of this evidence is considered to be moderate to high. Our study revealed a significant benefit of erlotinib in patient with EGFRWT tumors compared with other approaches. These findings add another therapeutic option to patients generally considered difficult to treat
RESUMEN
Targeting epidermal growth factor receptor [EGFR] is an important treatment option for non-small cell lung cancer [NSCLC]. These targeted therapies have been studied extensively in NSCLC in first line and subsequent lines, including maintenance in empiric fashion or in patients with tumors harboring the EGFR mutations. In this manuscript, we will review in details the evolutions of these targeted therapy in the management of NSCLC.