RESUMEN
Introduction: Rheumatoid arthritis is considered one of the most common, and particularly attacks the joint causing significant individual and community burden, and present with articular as well as extra articular manifestation. Treatment modalities of rheumatoid arthritis have dramatically improved in recent years, significantly decreasing long-term auricular and extra-auricular complications
Aim of the work: this review was aimed to study the pathophysiology, clinical picture, and management of rheumatoid arthritis, with focus on the newer modalities.
Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: rheumatoid arthritis, chronic inflammatory disorders, genetic of rheumatoid arthritis, management of rheumatoid arthritis, DMARD, biological agents
Conclusion: The newer modality of treatment must include disease-modifying antirheumatic drug [DMARDs] which must be started as early as possible. Combining DMARDs with corticosteroids will result in significantly better outcomes than monotherapy with any DMARD, and decrease long term morbidity associated with this condition
RESUMEN
Background: Malignant hypertension [MHT] is the most severe form of arterial hypertension
Objectives: Assessing the knowledge, attitude and practice [KAP] regarding the malignant hypertension in Kingdom of Saudi Arabia [KSA]
Methods: A cross-sectional questionnaire based study was conducted at 26 different hospitals in Saudi Arabia, Ministry of Health, from March to July 2018 among 260 interns
Results: This study showed a high level of knowledge and awareness among the respondent's regarding the malignant hypertension definition, cut off values, diagnosis, symptoms and treatment. The prompt knowledge was reflected by good attitude and practice among most of the interns. Most of the interns knew the definition of malignant hypertension, and the blood pressure values of hypertensive subjects without comorbidities, the difficulty in diagnosis of malignant hypertension and the importance of monitoring the blood pressure if suspecting malignant hypertension. Also, most of them showed good awareness of the targeted BP that would like to be achieved in hypertensive patients with diabetes mellitus and/or chronic kidney disease without proteinuria [87.5%]
Conclusion: The level of knowledge was sufficient among interns in KSA. Interns' knowledge about malignant hypertension is reflected in their attitude and practice