Membrane stabilizing action of cardio-selective Beta-adrenergic blocking agent [acebutolol] on the electrically stimulated diaphragmatic tissue of the rat

Isolated diaphragm of albino rats was prepared and effect of electric stimulation was observed before and after treatment of the tissue with the cardioselective beta-adrenergic blocking agent, acebutolol. Acebutolol did not produce no Significant effect on the response of tissue to electric stimulation in small doses. But in high dose, there was marked pression of the contractile effect of tissue to electric stimulation. It is concluded that this effect of acebutolol in high uses is due to the membrane stabilizing action of the drug