RESUMEN
Objective: To evaluate and compare the serum levels of visfatin, interleukin-6 and lipid profile in non-obese and obese male patients with coronary artery disease
Study Design: Observational, comparative study
Place and Duration of Study: Punjab Institute of Cardiology and Lahore General Hospital, Lahore, from July to December 2013
Methodology: The participants included 20 non-obese group I with coronary artery disease [CAD] and 20 obese males group II with coronary artery disease [angiographically confirmed]. All the participants were in the age group of 35 - 55 years being non-smokers and non-diabetic. Serum visfatin and interleukin-6 levels were analysed by Enzyme Linked Immunosorbent Assay [ELISA]. Lipid profile was also evaluated. Results were compared with T-test and Mann Whitney U test. The values were considered significant at 0.05 level of significance
Results: Serum visfatin 9.05 versus 3.9 ng/ml and interleukin-6 12.80 versus 0.60 pg/ml levels were significantly [p-value < 0.001 of both] raised in the obese CAD group as compared to non-obese with CAD. Lipid profile also showed raised levels of total serum cholesterol, low density lipoproteins, triglycerides, very low density lipoproteins and low levels of high density lipoproteins in obese group
Conclusion: Significantly raised levels of serum visfatin and interleukin-6 indicate adipose tissue as an imperative source of these adipocytokines involved in inflammation in CAD. Altered lipid profile also seen in obese patients with CAD
RESUMEN
Background: Resistin an adipocyte derived factor has cysteinc-rich C-terminal domain and has emerged as controversial link between obesity and type 2 diabetes mellitus [T2DM] in different studies and leads to dyslipidernia. This study was designed to determine and compare serum resistin, LDL and HDL levels in non-obese and obese type 2 diabetics
Methods: It was a cross-sectional analytical study in which eighty diabetic patients were recruited and were divided into two groups non-obese and obese on the basis of body mass index [BMI] and waist circumference [WC] [BMI 23, WC <90 Cm in group I and BMI >25, WC >90 Cm in group II]. Serum resistin was measured by commercially available ELISA Kit. Serum LDL and HDL levels were measured by direct quantitative measurement
Results: Higher serum resistin and LDL, and lower serum HDL levels were recorded in obese diabetics compared to non-obese diabetics. Significant positive correlation of serum resistin with LDL and negative correlation between serum resistin and HDL was present in all type 2 diabetics
Conclusions: The positive correlation of serum resistin with serum LDL and negative correlation with serum HDL suggests serum resistin to be a link between obesity and T213M and it may be responsible for altering lipid profile