An Interesting Case of Tuberculous Colitis Mimicking Crohn's Disease.

Intestinal tuberculosis is a rare disease in western countries and may mimic a variety of gastrointestinal disorders. Here, we report the case of a 29-yr-old male patient who presented with loose motions, loss of appetite and loss of body weight since two years. On colonoscopy transverse colon, ascending colon, caecum and ileocaecal mucosa was inflamed, swollen and showed multiple superficial longitudinal ulcerations. Crohn’s disease was suspected based on colonoscopic finding. However histopathological examination of biopsies from colonic mucosa then revealed caseating granulomas in the colonic mucosa typical for mycobacterium tuberculosis infection. Our diagnosis is supported by raised serum IgM levels.The patient responded nicely to antitubercular therapy. This case emphasizes the need to include intestinal tuberculosis in the initial differential diagnosis of ulcerative colorectal lesions.

Locally Confined Primary Signet Ring Cell Carcinoma of the Prostate with Immunohistochemical Analysis.

A case of locally confined primary signet ring cell carcinoma of the prostate in an 85 years old male with complaints of retention of urine, dysuria and frequent nocturia is reported. On per rectal digital examination, hard nodular prostate of grade 3 enlargement was palpated. Serum prostate specific antigen (PSA) level was 33.7ng/ ml. Chest x-ray and computed tomography of the pelvis was negative for metastatic disease. Hematological and biochemical investigations were within normal limits. Transurethral prostatic biopsy was done and histopathology revealed the diagnosis of poorly differentiated adenocarcinoma. Transurethral resection of prostate (TURP) with bilateral orchidectomy along with radiotherapy was selected as modality of treatment. After histopathological examination of TURP specimen with Haematoxylin and Eosin (H & E) and Periodic acid Schiff (PAS) stain, a diagnosis of primary signet ring cell carcinoma of prostate was given which was confirmed by immunohistochemical analysis.