analgesic and anti-inflammatory activities of the extract of albizia lebbeck in animal model

The extract of the bark of Albizia lebbeck Benth. obtained by cold extraction of mixture of equal proportions of petroleum ether, ethyl acetate and methanol was chosen for pharmacological screening. In rat paw edema model induced by carrageenan, the extract at the 400 mg/kg dose level showed 36.68% [p < 0.001] inhibition of edema volume at the end of 4h. In the acetic acid-induced writhing test, the extract at the 200 and 400 mg/kg dose level showed 39.9% and 52.4% inhibition of writhing, respectively. In radiant heat tail-flick method the crude extract produced 40.74% [p < 0.001] and 61.48% [p < 0.001] elongation of tail flicking time 30 minutes after oral administration at the 200 and 400 mg/kg dose level, respectively

Anti inflammatory and analgesic alkaloid from Sida cordifolia Linn

The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin - 3-ylamine [compound 1] isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 [p<0.05] and 52.43% [p<0.01] inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43% inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study