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Southeast Asian J Trop Med Public Health ; 1977 Jun; 8(2): 249-54
Artículo en Inglés | IMSEAR | ID: sea-35205

RESUMEN

Clinacanthus nutans Burm, a herb reputed in Thailand and Malaysia to be "snakebite antidote" has been tested in vitro and in vivo for antivenin activity. The aqueous extract of C. nutans leaves has been found to have no effect on the inhibition of neuromuscular transmission produced by purified Naja naja siamensis neurotoxin in isolated rat phrenic-nerve diaphragm preparations. The extract of C. nutans, when given orally or intraperitoneally, are ineffective in prolonging the survival time of experimental mice receiving lethal doses of N.n. siamensis crude venom. Oral administrations of the herb extracts pretreated with alpha-amylase or beta-amylase also fail to protect the animal. It is concluded that the extract of C. nutans can not antagonize the action of cobra venom.


Asunto(s)
Administración Oral , Amilasas/farmacología , Animales , Proteínas Neurotóxicas de Elápidos/antagonistas & inhibidores , Venenos Elapídicos/antagonistas & inhibidores , Inyecciones Intraperitoneales , Ratones , Unión Neuromuscular/fisiología , Nervio Frénico , Extractos Vegetales/uso terapéutico , Ratas , Mordeduras de Serpientes/terapia , Transmisión Sináptica
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