RESUMEN
Lipids are of one of the four basic types of molecules of life and its derivatives serve diverse functions in the body. Generally acclaimed functions of lipids include shock absorption and insulation, and energy storage of the body. Phospholipids and cholesterol form the integral part of cell membrane. In addition cholesterol serves as the precursor for bile salts, male and female sex hormones, vitamin D and adrenocortical hormones. Complex lipids consist of neutral lipid core of cholesterol esters and or triacylglycerol and proteins are the chylomicrons, VLDL, LDL and HDL which serve as the carriers of fats, fatty acids and other lipids in the body. Complex lipids are tightly controlled in the body. Its dysregulation has been mainly linked to obesity, diabetes and insulin resistance though the issue is yet to be clearly understood. The present review evaluates recent reports in this regards and try to explain the relationship between dyspidemia and insulin resistance.
RESUMEN
Introduction: Hs-CRP is a nonspecific marker of the inflammatory response has been associated with development of type 2 diabetes mellitus. Cardiovascular disease is a major consequence of diabetes. DM confers a 2-4 fold rise in cardiovascular risk compared with general population. One of the many modifiable risk factors for both cardiovascular disease and diabetes is diet. Fiber is an important dietary factor that may modify the risk of both diseases. Material & methods: The current study is an attempt to explore the association of dietary fiber on inflammatory marker, hs-CRP in type2 diabetic subjects. Total 80 diabetic subjects were included in this study of which 40 were taking more dietary fiber and 40 were taking relatively low dietary fiber. Serum hs-CRP was measured by chemiluminescent immunometric assay (DPC Biermann Gmbh., Germany). Nutrient information was calculated using a pretested food recall questionnaire prepared by nutritionists for usual Bangladeshi food articles. Results: Hs-CRP was significantly higher in subjects taking low dietary fiber. There was significant negative correlation between CRP of subjects taking high and low intake of dietary fiber. Conclusion: So, low dietary fiber consumption maybe a possible causal factor of raised CRP. Type 2 diabetic patients who took less dietary fiber in their diets had elevated blood CRP levels.
RESUMEN
Metabolic syndrome and insulin resistance has been the subject of much debate over the last two decades. Its pathophysiologycal basis, however, still remains to be clearly understood. Both genetic and environmental factors have been implicated in its pathogenesis. Mutation of genes encoding signal transduction molecules of insulin and acquired factors like aging, diets, physical activity, obesity and related molecular changes, dyslipidemia, hypertension and smoking were proposed by many groups. This review examined both acquired and genetic factors and discussed model of hormone-receptor-postreceptor interactions to explore the molecular basis of insulin resistance.