RESUMEN
Objective: Frameless stereotactic biopsy has been shown in multiple studies to be a safe and effective procedure for the diagnosis of brain lesion. In this study the authors will evaluate the safety of the procedure and associated complications including neurological deficits in our set up of developing countries
Methods: Forty two patients with different brain lesions were biopsied using frameless stereotactic procedure between the periods of March 2009 - March 2014 for the assessment of diagnostic yield and related complications
Results: During the study period, forty two patients were biopsied for the evaluation of the complications related to the biopsy site. Neurological decline occurred in 1 patient. A higher number of needle passes was associated the presence of a postoperative hematoma. Infection occurred in one patient and overall diagnostic yield was 95%
Conclusion: Frameless stereotactic biopsy is a safe and effective method of tissue diagnosis for small lesions located in the eloquent and non-eloquent region of brain. With careful planning, frameless biopsy remains a valuable and safer tool for diagnosis of brain lesion, independent of the location of these lesions
RESUMEN
Purpose of the study: To study the relationship between Gleason's Score with age, cellularity of Tumor and PSA immunohistochemical staining in prostatic carcinoma
Basic procedures: An exploratory study carried out at the Department of Histopathology of a Tertiary Care Hospital Lahore, from January 1999 to July 2002. Sixty-two [62] cases of prostatic adenocarcinoma were graded with Gleason's score and degree of cellularity of the prostatic cancer were determined on each slide, along with degree of positive staining with immunohistochemical stain marking tissue PSA. These were correlated and relationship was evaluated by ANOVA and simple regression
Main findings: Age of the 62 cases ranged between 50 - 90 years and no significant difference was found between age groups regarding tumor cell differentiation. Cellularity of the prostate cancer showed a weak positive relationship with Gleason's score. Relationship between staining positivity and Gleason's score showed an inverse quadratic relationship with an F statistic of 76.2 [p.0001] and Beta of -.75
Conclusions: From this study it can be concluded that cellularity of tumor tissue in a specimen bears little or no relationship with Gleason's Score. There is an inverse relationship between Gleason's Score and percentage of tumor cells showing positive staining with PSA immunohistochemical stain