RESUMEN
PURPOSE: To document the clinical pattern in recurrent herpes simplex disease. METHODS: Eyes with clinically documented pattern of corneal manifestation on more than one occasion were analysed. For each eye recruited, the clinical pattern of the disease at each recurrence of herpes simplex corneal disease, age, disease-free intervals, triggering factors, laterality and steroid abuse were noted and evaluated. RESULTS: For an average follow up of 6.9 years, a recurrence rate of 0.6 episodes per year was observed. Disease-free intervals of 75.7 months for epithelial herpes simplex disease was considerably longer than the 21.3 months observed for stromal disease. Clinical pattern of recurrence was of the same type following first episode of disciform keratitis, epithelial keratitis and endothelitis in 84%, 72.7%, and 75% of the eyes respectively. CONCLUSION: Herpes simplex disease often recurs in the same manifest clinical pattern as the first episode. This clinical evidence provides additional support for the potential role of herpes simplex biotypes in determining manifestation of clinical disease pattern.
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Queratitis Herpética/patología , Funciones de Verosimilitud , Masculino , Persona de Mediana Edad , Recurrencia , Estudios RetrospectivosRESUMEN
Ninety four patients of generalised and partial epilepsy were randomly assigned to treatment with sodium valproate (49 cases) or phenytoin (45 cases). Serum levels were monitored. Cases were evaluated after 4, 12, 24 weeks of treatment. Both drugs were found to be equally effective in controlling generalised seizures. However, valproate is better in partial seizures. No correlation could be established. Side effects were minor with both the drugs.
Asunto(s)
Adolescente , Adulto , Niño , Epilepsias Parciales/tratamiento farmacológico , Epilepsia Generalizada/tratamiento farmacológico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fenitoína/sangre , Ácido Valproico/sangreRESUMEN
A general presentation is made of data derived from systematic trend studies on the Anopheles fauna in 12 study villages of Orissa State, India. Adult and larval species prevalences, seasonal densities of prominent anophelines and predilections of various species to feed on human blood are discussed and demonstrated.
Asunto(s)
Animales , Anopheles/clasificación , Bases de Datos Factuales , Humanos , India/epidemiología , Insectos Vectores , Larva , Estudios Longitudinales , Malaria/epidemiología , Prevalencia , Estaciones del Año , Especificidad de la EspecieRESUMEN
Ninety patients with aluminum phosphide poisoning have been studied over a period of 3 years. Epigastric pain and vomiting were the common initial clinical features, followed 12 to 24 hours later by cardiogenic shock, oliguria, altered mental state and respiratory distress. Death occurred within 24 to 72 hours presumably due to poison-induced toxic chemical myocarditis as reflected by electrocardiographic changes. The overall mortality was 63.3%. Intravenous magnesium sulphate, probably due to its membrane stabilizing action, appears to be related to the reduction in mortality from 90% to 52% in the latter 62 cases.