Mecanismes moleculaires de la leucemie myeloide chronique

Chronic myeloid leukaemia is a hronic disorder of the pluripotent hematopoietic stem cell chracterised by reciprocal chromosomal translocation, Ph chromosome. Molecular haematology development is one stage of the progress in diagnostic and therapeutic care of malignant hemopatology. In this review, wwe report the molecular mechanisms of chronic myelogenous leukaemia that include chimerics gens and protein. The deregulated tyrosine kinase activity gives excessive proliferation. Inhibition of the expression of the tyrosine kinase by Imatinib [STI571, GLIVEC] is therapeutic manoeuver