RESUMEN
Twelve subjects had an ill fitting lower denture, and were selected for clinical and cytological studies. Infrared spectroscopic study was done on 40 test discs of self-cure resin. The results of the present study indicated that, clinically, the mucosal irritation was expressed at the first 5 days of the study, and by the end of the 7th day. It completely subsided. Cytologically, there was an apparent loss of epithelial cells at the first 5 days of the investigation, followed by the formation of keratinized cells as protective layer from irritant agent beginning at the seventh day. Infrared spectroscopic analysis indicated that there was no hydroxyl absorption either aliphatic [due to ethylene glycol] or aromatic [hydroquinone]. So, both materials were reached directly with the acrylate present in the polymer and the monomer to form a long-chain polymer