RESUMEN
Background: Multiple pregnancies occur more frequently in assisted reproductive technology [ART] compared to normal conception [NC]. It is known that the risk of congenital malformations in a multiple pregnancy are higher than single pregnancy. The aim of this study is to compare congenital malformations in singleton infants conceived by ART to singleton infants conceived naturally
Materials and Methods: In this historical cohort study, we performed a historical cohort study of major congenital malformations [MCM] in 820 singleton births from January 2012 to December 2014. The data for this analysis were derived from Tehran's ART linked data file. The risk of congenital malformations was compared in 164 ART infants and 656 NC infants. We performed multiple logistic regression analyses for the independent association of ART on each outcome
Results: We found 40 infants with MCM 29 [4.4%] NC infants and 14 [8.3%] ART infants. In comparison with NC infants, ART infants had a significant 2-fold increased risk of MCM [P=0.046]. After adjusting individually for maternal age, infant gender, prior stillbirth, mother's history of spontaneous abortion, and type of delivery, we did not find any difference in risk. In this study the majority [95.1%] of all infants were normal but 4.9% of infants had at least one MCM. We found a difference in risk of MCMs between in vitro fertilization [IVF] and intracytoplasmic sperm injection [ICSI]. We excluded the possible role of genotype and other unknown factors in causing more malformations in ART infants
Conclusion: This study reported a higher risk of MCMs in ART singleton infants than in NC singleton infants. Congenital heart disease, developmental dysplasia of the hip [DDH], and urogenital malformations were the most reported major malformations in singleton ART infants according to organ and system classification
RESUMEN
Background: cirrhosis, the end stage of progressive hepatic fibrosis, is characterized by distortion of the hepatic architecture and the formation of regenerative nodules. Liver transplantation is one of the few available therapies for such patients. However, due to a severe shortage of organ donors, surgical complications, transplant rejection and the high cost of this procedure much interest has focused on research to find new treatment modalities for this disease. There is accumulating evidence for the contribution of bone marrow stem cells to participate in liver regeneration
Methods: here we report on six patients with end stage liver disease who were subjected to intraportal administration of autologous bone marrow-derived CD133+ in comparison to mononuclear cells in short-term [6 months] and long-term [24 months] follow up
Results: there were no adverse effects in any of the patients during the short- and long-term follow up period. Moreover, there were no significant alterations of liver function parameters, liver enzymes, serum albumin, creatinine, serum bilirubin and/or liver volume after transplantation of both types of autologous cells in these patients
Conclusion: our study has shown both the safety and feasibility of this type of liver cell therapy and may be a bridge to liver transplantation. The trial was registered with NIH clinical trials [www.clinicaltrials.gov] as identifier: NCT00713934