RESUMEN
Oxidation of low-density lipoprotein [LDL] is believed to be a key factor in the development of atherosclerosis. Oxidative modification of LDL is associated with increased uptake of these particles by the macrophage receptors located in the arterial wall which in turns would lead to accumulation of lipids within the cytoplasm of the cell and formation of the foam cells, a perquisite step in the development of the atherosclerotic plaque. The aim of the present study was to evaluate the association between serum Ferritin and oxidized low-density lipoprotein in coronary artery disease [CAD] patients. The study group consisted of 160 males [mean age [47 +/- 7] years] with suspected CAD and no history of renal, liver and diabetic disorders undergoing coronary angiography. Oxidized LDL and Ferritin levels were measured by ELISA methods. Results obtained from the study revealed that the mean serum Ferritin concentration in our study population was 149.77+119.93 ng/ml and that of OX-LDL was 8.86+5.67 IU/L. Serum Ferritin levels were significantly correlated with both OX-LDL concentrations [p=0.001, r=0.24] and CAD SCORE [p=0.005, r=0.208] in study patients group; however no correlation was detected between OX-LDL and CAD SCORE [p>0.9]. The present study is the first to report serum Ferritin levels is associated with circulating OX-LDL level in patients with CAD. The correlation of CAD SCORE with Ferritin levels in these patients is indicative of the importance of this parameter in predicating CAD. These results suggest that measurement of OX- LDL and Ferritin could be of great assistance in predicating premature CHD.
RESUMEN
The aim of this study was to determine incidence of cardiovascular disease [CVD] risk factors [hypertension [HTN], obesity, Dyslipidemia[DLP], diabetes mellitus [DM] and smoking] in Oskoo. This study was planned according to WHO protocol [WHO CVD-risk management package for low and medium-resource settings] and named [East Azerbaijan healthy heart program]. The pilot study of this program was done in Oskoo in 2007-2009. In this study, demographic data and CVD risk factors of 37, 329 adults aged>30 years old living in Oskoo were collected. In addition, blood samples of 17, 388 adults>40 years old were taken [free of charge] for assessment of serum glucose and lipid profile. The study covered 93.52% of Oskoo town population aged>30 years old. We studied 18637 male [M] [91.50% coverage] and 18692 female [F] [95.52% coverage] participants. The incidence of HTN [SBP>140 and DBP>90 mmHg] was 16.25% [M:15.08%, F: 17.29%], pre-hypertension [SBP-120-139 and DBP-80-89 mmHg] -37.78% [M:41.38%, F:34.18%], DM [fast blood glucose [FBS]>126mg/dl] was 7.45% [M:6.35%, F:8.54%], smoking was 9.40% [M: 17.00%, F:1.57%], hypercholesterolemia [>200mg/dl] was 47.64% [M:42.46%, F:52.81%] and obesity [body mass index [BMI] >27] was 50.47% [M:38.79%, F:62.09%]. Considering high incidence of CVD risk factors [except smoking] in Oskoo adults >30 years, it is recommended that this pilot study expanded to all of East Azerbaijan. Free of charge taking blood samples from people > 40 years to evaluate lipid profile and glucose levels is worthy to early detecting the prevalent