RESUMEN
Introduction: Alkaline caustics and acids are the most common chemicals implicated in caustic burns. Stricture formation with inability to swallow food after the injury is inevitable in some cases. As for the complications and ineffectiveness of the dilation in more severe strictures, colonic transposition serves as a better replacement for the esophagus. Aim: This study aims to study the adequacy of colonic transposition done for cases of corrosive esophageal strictures and to discuss the complications and their management and the outcome of therapeutic measures employed. Materials and Methods: A total of eight adults with corrosive esophageal strictures were studied at M S Ramaiah Teaching Hospital for 2 years from October 2012 to December 2014. Results: Of the eight patients, who were studied, five were male and three were female. Intentional mode of corrosive intake was higher (n = 5) and acidic corrosive was more commonly ingested (n = 6). Upper esophageal stricture was seen in five patients. Colonic transposition + feeding jejunostomy (FJ) was done in eight patients, of which two patients underwent transhiatal esophagectomy+colonic transposition+FJ. Complications were seen in 50% of the patients with 38% having anastomotic leak and 12% having anastomotic stricture which were managed conservatively. All the eight patients had improved outcome of life. Conclusion: Colonic transposition is a good and effective conduit for the management of corrosive esophageal strictures.
RESUMEN
Diabetes mellitus is the most common human disease and there is growing interest for plant based therapy in managing diabetes mellitus specifically in the developing world. In the present study, Rhazya stricta Decne extract was analysed for its antidiabetic activities. Crude methanolic extracts of different plant parts were tested in vivo on albino mice Balb-C, for the reduction of blood glucose, urea, cholesterol, triacylglycerides and glycosylated haemoglobin. Results obtained showed that leaves of R. stricta have best antidiabetic effect by reducing blood glucose level, Glycosylated haemoglobin, triacylglycerides and Cholesterol in hypergly-caemic mice. The R. stricta leaves extract being most active was further fractionated by solvent extraction using n- Hexane, ethyl acetate, chloroform and water and all fractions were tested for same activities. It was found that ethyl acetate fraction is most effective in the reduction of blood glucose level at fasting and random conditions and blood glucose reduction was comparable to Glucophage, a standard antidiabetic drug. The present study suggests that Rhazya stricta leaves extract and its ethyl acetate fraction has great potential for development of antidiabetic drug.
RESUMEN
Diabetes mellitus is the most common human disease and there is growing interest for plant based therapy in managing diabetes mellitus specifically in the developing world. In the present study, Rhazya stricta Decne extract was analysed for its antidiabetic activities. Crude methanolic extracts of different plant parts were tested in vivo on albino mice Balb-C, for the reduction of blood glucose, urea, cholesterol, triacylglycerides and glycosylated haemoglobin. Results obtained showed that leaves of R. stricta have best antidiabetic effect by reducing blood glucose level, Glycosylated haemoglobin, triacylglycerides and Cholesterol in hypergly-caemic mice. The R. stricta leaves extract being most active was further fractionated by solvent extraction using n- Hexane, ethyl acetate, chloroform and water and all fractions were tested for same activities. It was found that ethyl acetate fraction is most effective in the reduction of blood glucose level at fasting and random conditions and blood glucose reduction was comparable to Glucophage, a standard antidiabetic drug. The present study suggests that Rhazya stricta leaves extract and its ethyl acetate fraction has great potential for development of antidiabetic drug.