RESUMEN
Hodgkin disease is a lymphoid tumor that accounts for less than [1%] of all DeNovo neoplasms occurring every year worldwide. The aims of the study was to assess the expression of immunohistochemical markers namely [CD[20], CD[15] in malignant cells of Hodgkin's disease. Over the period extending from [January 2006-March 2008], specimens form 31 cases of lymphocyte predominance Hodgkin lymphoma [Rye's classification] as formalin fixed, paraffin embedded tissue blocks from excisional lymph node biopsies. For each case, five representative sections were prepared. One stained with hematoxyline and eosine [HxE], and four other sections [on positively charged slides] prepared for IHC procedures using CD[15], and CD[20]. For the evaluation of markers expression, a semiquantitative evaluation system was used to register the staining intensity and the numbers of positive cells. The most common site of lymph node biopsy was the cervical lymph node in [61.2%] of cases. Immunohistochemically, CD[20] was expressed in [12.9%] of cases, while CD[15] was expressed in [77.4%] of cases. This study has shown that HD with a nodular growth pattern and a lymphocyte-rich background encompasses 2 entities with distinct morphologic, phenotypical features. Therefore, the precise classification of such case requires a combination of conventional histology and immunohistology with distinct panel of antibodies