Efficacy of volatile oils [curzerene, furanoeudesma-1, 3-diene and lindestrene] on avian coccidiosis under laboratory conditions

The coccidicidal efficacy of volatile oils [curzerene, furanoeudesma-1, 3- diene and lindestrene] against unsporulated and sporulated chicken Eimeria species oocysts was tested in three concentrations: 1, 2 and 3 micro g/ml. Marked reduction in the number of living oocysts was recorded in exposed groups. The concentration of 3 micro g/ml volatile oils induced the highest destructive effect. 58.1% of viable unsporulated oocysts were destroyed. A mean number of 153,800 oocysts was the difference between the total number of the produced oocysts per gram faeces in the group infected with exposed oocysts and that of the group infected with nonexposed oocysts being less in the exposed group with more reduction in the vitality of shedding oocysts in the former group. At the meantime, the postmortem and histopathological microscopical examination of the intestine and caecum of' the tested group revealed a reduction in the intestinal lesions in the group infected with the exposed oocysts

Mirazid in treatment of human Hymenolepiasis

The efficacy and safety of Mirazid in treatment of human hymenolepiosis were carried out in a rural village in Talkha Center [Dakahlia G.]. Kato thick smear stool examination showed 51 cases of Hymenolepis nana [9 of them had concomitant parasitosis], two cases of H. diminuta. Mirazid was given in a dose of 10 mg/kg/d for nine consecutive days an hour before breakfast for hymenolepiosis cases, as capsule for adults and suppository for children. All cases were subjected to history taking before treatment and six weeks post-treatment and stool examination was repeated as well weekly for six weeks post-treatment. There was overt clinical improvement. Side effects were negligible. Parasitologic cure rate was 40/41 or 95.2% for H. nana one week post-treatment, and 100% for H. diminuta one week post-treatment, up to six weeks follow-up for all treated patients. Two unresponded H. nana patients were cured by another Mirazid course

In vitro effect of mirazid on schistosoma mansoni worms

Measuring mirazid ability for contracting the worm muscle and its effect on the worm surface ultrastructure can be used to monitor the in vitro effect of any drug. This study aimed to investigate the actual effect of mirazid [a new schistosomicide, purified oleo-resin extract of myrrh, derived from Commiphora molmol plant] on S. Mansoni worms by detecting its in vitro effect. Three groups of white albino mice [five mice in each group] were infected by 100 cercariae for each mouse. The 3rd group served as a control group. Seven weeks post- infection, the mice were sacrificed, perfused and worms were collected. Muscle tension of the worms collected from the first group of mice was assayed in response to mirazid in rising concentrations of 100, 200, 300 and 400 nM. The in vitro effect of mirazid on the muscle tension of single S. Mansoni worm was determined using a special device to determine the percentage of change in work length [% shortening]