Changes in sinus mucosa after endoscopic sinus surgery

This study was conducted on a group of 30 patients suffering from chronic sinusitis and control group of 15 patients in a period of two years. Chronic sinusitis group was evaluated by pre-operative C.T. scan. Which was performed with [General electric scan 9800]. Post-operative C.T. scans were taken for follow up.Diagnostic nasal endoscopy was performed at the time of the initial evaluation at the out patient clinic. Evaluation was performed under topical an aesthesia After decision had been made to proceed with F.E.S.S. the first biopsy was taken during surgery and the second biopsy was taken after improvement from O. M.C. ordinary histologic examination with haematoxyline, eosin and toluidine blue ultrastructural examination by Transmission Electron microscopy and Scannng Electron Microscopy results concluded that: use of functional endoscopic sinus surgery to remove the local pathological lesion [affecting Ostio Meatal complex] is a main factor in gradual regeneration of the paranasal sinus mucosa

Evaluation of sodium cromoglycate in treatment of inhalational nasal allergy

This study includes 30 patients with inhalational allergic rhinitis and 15 controls who attended the E.N.T. clinics in Al-Azhar University Hospitals. Patients were diagnosed clinically and laboratorally as suffering from inhalational nasal allergy. Study population consisted of 20 male, 10 female, of the age between 15-60 years in which there was a positive family history of allergy in most patients. Rhinoscopy revealed mainly a place nasal mucosa and clear mucoid secretions. Biopsy specimens for this group were taken from the inferior turbinates under local anaethesia without the use of topical vasoconstrictors. Biopsies from the turbinates were studied by light, transmission and scanning electron microscopes to assess the effect of sodium cromoglycate spray orn nasal mucosa in cases of inhalational nasal allergy. In patients treated by sodium cromoglycate; light and electron microscopic examination showed mainly pseudostratified columnar ciliated epithelium with varying degrees of epithelial hyperplasia, windened intercellular spaces, loss of some cellular membrane, cytoplasmic vacules, ciliary loss and destruction. After treatment they showed improvement of the surface epithelium and decrease of mast cell degranulation