COMBINED ANTITUMOR EFFECT OF LYSINE-GERMANIUM AND CYCLOPHOSPHAMIDE ON S-180 SARCOMA IN MICE / 中国药理学通报

Lysine-germanium ( Ge401 ) was a newly synthesized organoger-manium compound in China. The LD50 of Ge401 for mice was 9.26 and 5.62 g/kg po and ip administrations. The inhibition rates of subcutaneously transplanted S-180 sarcoma in mice were 25%, 32% and 55% respectively when ip, po and iv administrations of Ge401 were used. The antitumor activity of cyclophosphamide (30 mg/kg? 2d-1, ip ) in S-180 bearing mice was significantly potentiated by Ge401 (30 mg/kg?d-1, iv ) .