RESUMEN
Diabetes mellitus is a chronic ailment that impairs the production of or response to insulin, a hormone that helps to convert food into energy. Its complications are responsible for excess morbidity and mortality, loss of independence and reduce quality of life. Among the major cause of disablement and early death are ischemic heart disease, retinopathy, nephropathy, peripheral vascular disease and neuropathy. Insulin replacement therapy has been used in the clinical management of diabetes mellitus for more than 85 years. As subcutaneous injection is a painful episode so various approaches like transdermal, pulmonary, intranasal, colon targeted delivery, oral delivery is tried as an alternative way. Among them oral delivery is the challenging one because insulin cannot administered orally due to rapid enzymatic digestion in stomach. For oral delivery various technology, formulation and various modification approaches are going on. It is high time to invent an acceptable non-invasive insulin delivery for the diabetes to improve patient compliance and decrease the morbidity.
RESUMEN
Diabetes mellitus is a chronic ailment that impairs the production of or response to insulin, a hormone that helps to convert food into energy. Its complications are responsible for excess morbidity and mortality, loss of independence and reduce quality of life. Among the major cause of disablement and early death are ischemic heart disease, retinopathy, nephropathy, peripheral vascular disease and neuropathy. Insulin replacement therapy has been used in the clinical management of diabetes mellitus for more than 85 years. As subcutaneous injection is a painful episode so various approaches like transdermal, pulmonary, intranasal, colon targeted delivery, oral delivery is tried as an alternative way. Among them oral delivery is the challenging one because insulin cannot administered orally due to rapid enzymatic digestion in stomach. For oral delivery various technology, formulation and various modification approaches are going on. It is high time to invent an acceptable non-invasive insulin delivery for the diabetes to improve patient compliance and decrease the morbidity.
RESUMEN
A new, simple, specific, sensitive, rapid and economical procedure has been developed for determination of Nitroglycerin in its dosage form. The objective of this validation of an analytical procedure is to demonstrate that the drug Nitroglycerin is suitable for its intended purpose. The analytical method development recommends the quality, purity and specificity of the drug Nitroglycerin tablet form during the manufacturing process and hence the standard of the drug may not vary, which produce the desirable therapeutic effect. The method is based on the ultraviolet absorbance maxima of the above drug at 210nm. The drug obeyed Beer's law in the concentration range of 15μg/ml in methanol. The proposed methods were successfully applied for the determination of drug in commercial tablet preparations. The results of the analysis have been validated statistically and by recovery studies.