RESUMEN
Objective: To compare frequency of Hyperprolactinemia with Risperidone and Olanzapine in patients with first episode psychosis
Study Design: Randomized controlled trial
Place and Duration of Study: Combined Military Hospital [CMH] Lahore, over a period of six months from Sep 2015 to Feb 2016
Subjects and Methods: Total 60 patients who had psychosis as accompanying feature in any of the various psychiatric illnesses according to ICD-10 diagnostic criteria were enrolled in this Randomized controlled Trial. Fasting venous blood samples for serum prolactin were collected between 0800 hrs and 1000 hrs at baseline [first visit]. The patients were then randomly assigned to receive risperidone or olanzapine by lottery method. Serum prolactin levels were then collected at 3 months follow-up visit. All samples were tested in labortary of Pathology department, CMH Lahore for measurement of serum prolactin levels and results were verified by a classified pathologist. Confounding variables were identified and excluded by exclusion criteria
Result: A total of 35 patients [58.33 percent] developed hyperprolactinemia. The olanzapine group showed 13 out of 30 patients [43.33 percent] and risperidone group showed 22 out of 30 patients [73.33 percent] with raised prolactin levels with p-value of 0.018 indicating that the difference was statistically significant
Conclusion: Frequency of hyperprolactinemia is high with risperidone than with olanzapine in first episode psychosis
RESUMEN
The objective of the study was to determine the effect of Electro Convulsive Therapy [ECT] on cognitive functions in patients of depressive episode. Design and It was an observational analytical study conducted in Departments of Psychiatry Military Hospital Rawalpindi and the Naval Hospital [PNS Shifa] Karachi. Fifty-five patients with depressive episode who were to undergo ECT treatment were included. They were administered translated versions of Mini Mental State Examination [MMSE] 24 hours before first ECT and 3 hours after first, second, fourth and sixth ECT and one month after the last ECT. Pre ECT cognitive functions were compared with those after subsequent ECTs. Data was compiled and analyzed by using Statistical Package for Social Sciences [SPSS] version 10.0 calculating mean values and p-value for determining the significance of difference which was set at 0.05. Mean age of the subjects was 29 years. Thirty-nine [71%] were males, 16 [29%] were females; 24 [44%] were taking tricyclic antidepressants as compared to 31 [56%] who were on other antidepressants. ECT had a significant effect on registration and recall of memory in the depressed patients who underwent six ECTs given by bilateral electrode placement and this persisted one-month after the last ECT. There was no significant effect of ECT on orientation, attention and concentration component of cognitive functions one month after last ECT. Language functions including comprehension and articulation remained unaffected. This study finds no persistent cognitive impairment after 30 days in patients treated with ECT, except for a decline in registration and recall aspects of short term memory