15-year experience with verrucous carcinoma of the urinary bladder: pathological review and long term follow-up

To evaluate the outcome after the treatment of verrucous carcinoma of the bladder. 62 patients with verrucous carcinoma of the bladder diagnosed and treated by standard radical cystectomy [or anterior pelvic excentration in females] and urinary diversion at Cairo National Cancer Institute hospital in the years 1989-2004. Pathological review of these patients was performed, follow up data were collected and disease free survival was estimated using Kaplan Meier method. Stage P[1] and stage P[2] patients represented 77.4% of the treated patients. 10 patients had typical verrucous carcinoma and 52 had invasive verrucous carcinoma. The 5 year Disease Free Survival was 90.6% for all patients. For equal stages of bladder cancer, verrucous carcinoma has the best prognosis. Patients with this special type of bladder cancer deserve the opportunity of nerve sparing modified radical cystectomy and an orthotopic continent neo-bladder diversion

Concordance of relapse and stage progression with angiogenesis, P53, PCNA and DNA ploidy in low-grade superficial transitional cell carcinoma of urinary bladder: a clinicopathological study

The present study was undertaken to evaluate some molecular pathologic parameters as prognostic factors in low-grade superficial urinary bladder carcinoma. Twenty cases of low-grade [G1/G2] and superficial [T1] transitional cell carcinoma were included in this study with a follow up period of 30 months. A recurrence was noticed in 14 cases, while 6 cases showed no recurrences. Among the recurrent tumors, six patients developed subsequent muscle invasion and subjected to radical cystectomy. A total of 71 paraffin blocks were available for the study from the initial as well as the recurrences. They were submitted to microvessel count, using factor VIII related antigen, p53 expression, PCNA immunoreactivity and DNA ploidy, using CAS 200-image cytometer