RESUMEN
The objective of study was to determine chloroquine resistant malaria to children admitted in children ward unit I of Liaquat Medical College Hospital. 210 cases of suspected malaria were admitted in study year Oct 94 to Sep. 95. 80 cases had MP+ve and had no other cause of illness. 60 MP+ve cases were treated with chloroquine out of which 22 cases i.e. 36.6% were resistant Chloroquine resistant cases were treated with iv quinine which showed good response in 84.3% cases. 20 MP+ve cases were given iv quinine as initial treatment and 5% resistance was seen. Overall mortality was 3.7%. The study shows that there is high resistance to chloroquine in the area and IN quinine should be used as fust line antimalarial in severe cases of falciparum malaria