Prevalence of HBs Ag in adults needing endoscopy and its likely aetiological factors

A total of 1200 patients needing endoscopy for upper and lower Gastrointestinal symptoms were screened for HBsAg at the DHQ Teaching Hospital of Ayub Medical College Abbottabad, using the Hepatitis-B Quick Test of the 1200 patients 553 were females and 647 males. Amongst these 40[3.33%] were HBsAg positive, of which 16 were male and 24 female. 33[82%] patients gave a history of parenteral injection; 24 [60%] of I/V infusion and 5[12.2%] had no history of injections/infusion or transfusion. The above figures suggest that HBsAg is not as common in Hazara as compared to studies done in bigger towns of Pakistan secondly parenteral therapy seems to be the most important mode of transmission. In order to further reduce the incidence we need to educate the people the paramedical staff and laboratories dealing blood transfusions

Lansoprazole in the treatment of acute peptic ulcer disease

This is an open study conducted by the gastro-enterology department of Ayub Medical College, Abbottabad. The aim was to study the effect and tolerance of lanso-prazole in peptic ulcer disease, in a dose of 30 mg nocte. A total of 15 patients completed the trial, [Oesophageal ulcers 4, Gastric ulcers 4, Duodenal ulcers 7]. Assessment was made clinically and endoscopically. The healing rate at the end of 6 weeks was 100%. The drug was well tolerated with no side effects. Most of these patients had taken H[2] receptor antagonists without benefit. In conclusion lansoprazole is an effective and safe drug in healing acute peptic ulcers and is well tolerated

Co-relation of dyspepsia with upper gastrointestinal pathology in the northern areas of Pakistan

This is a trial done over a period of two years, in which 400 patients, with persistent dyspepsia were endoscoped. The majority of the patients had gastritis. Other disorders found in order of frequency were oesophagitis duodenal ulcer and gastric ucler. Duodenal ulcer was found to be three times more common than gastric ulcer. Carcinoma of oesophagus was found almost twice, as common as carcinoma of the stomach. About one fifth of the patients has no Pathology. Compared with other studies we found to peptic ulcers, carcinoma and gastritis were more common in our study

Correlation of endoscopic finding with histological, diagnosis in gastritis

Twenty five [14 male and 11 female] gastritis cases diagnosed on endoscopic examination revealed some form of inflammatory lesion of gastric mucosa. All the cases were biopsied for histological confirmation of diagnosis. Nineteen of 25 had histological evidence of the disease while 6 showed no histological changes. Thus in about 76% cases there was positive correlation between endoscopic and histopathological diagnosis

Famotidine in acute duoendal ulcer

This is a 8 week open study in which the effect and tolerance of Famotidine, in a dose of 40 mg nocte was tried for the treatment of duodenal ulcer in 22 patients. Assessment was made clinically, biochemically and endoscopically. The healing rate at the end of 8 weeks was 95.45%. The drug was well tolerated with no significant side effect. In conclusion, Famotidine is an effective and safe Duodenal ulcer healing drug, which is well tolerated and has minimal side effects