RESUMEN
@#A high presence of periodontal pathogens such as Porphyromonas gingivalis (P. gingivalis) has been found in cancers at different body locations. The imbalance of the oral microbiome (dysbiosis) promotes the chronic inflammatory process that could contribute to carcinogenesis. To assess the P. gingivalis detection in cancer patients. A search for studies on P. gingivalis and neoplasms was conducted from 1974 to 2021 in the following databases: PubMed (MEDLINE), Cochrane Library, Web of Science (WoS), and Scopus. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using MantelHaenszel (M-H) method with 95% confidence intervals. Funnel plot and Egger’s test for publication bias analysis were used. Also, Newcastle-Ottawa (NOS) studies methodological quality assessment scale was employed. Thirteen studies that involved 1732 cancer patients and 3298 controls without cancer were included in this meta-analysis. P. gingivalis detection was 1.81 times more likely in cancer patients (p<0.01) compared to controls. P. gingivalis detection was also more likely in patients with colorectal (OR: 2.00, p=0.02) or pancreatic (OR: 1.32, p=0.02) tumors. In contrast, oral, esophageal, lung, or breast cancers did not show a significant increase of P. gingivalis detection (p>0.05).
RESUMEN
The purpose of this study was to assess the efficacy of alexidine (ALX), alone and combined with N-acetylcysteine (NAC), in eradicating two Enterococcus faecalis strain biofilms. The biofilms of E. faecalis ATCC 29212 and the clinical isolate E. faecalis D1 were grown in the MBEC-high-throughput device for 24 h and were exposed to five twofold dilutions of ALX (2%-0.007 8%) alone and combined with 100 mg⋅mL(-1) NAC, for 1 and 5 min. Eradication was defined as 100% kill of biofilm bacteria. The Student's t-test was used to compare the efficacy of the associations of the two irrigants. After 1-min contact time, ALX eradicated the biofilms at all concentrations except for 0.007 8% and 0.015 6%-0.007 8% with E. faecalis ATCC 29212 and E. faecalis D1, respectively. Similar results for eradication and concentration were obtained when it was combined with 100 mg⋅mL(-1) NAC. After 5 min of contact time, ALX alone and combined with NAC eradicated all enterococci biofilms. ALX showed antimicrobial properties against the two E. faecalis strain biofilms tested at very low concentrations, and its combined use with NAC was not seen to enhance its activity.