Some aspects of drug interaction: C-immunological studies of rabbits treated with progesterone and diazinon

The immune status of rabbits treated with 1.5 mg progesteron and 2.5 mg/kg body weight diazinon were investigated. There was a sharp decrease in spleen plaque forming cells, revealed concentration of plasma cells, antibody titres detected by passive haemagglutination test and delayed skin hypersensitivity reaction in rabbits treated with diazinon only and in rabbits treated with progesteron and diazinon. It was noticed that the progresteron and diazinon act as antagonists and they induce immunosuppressive effects