RESUMEN
We report a case of large iris melanocytoma in a child diagnosed by fine needle aspiration biopsy. In this interventional case report, cytologic features typical of melanocytoma were obtained by fine needle aspiration biopsy [FNAB]. FNAB can be used in difficult diagnostic cases if a good sample is obtained, this technique has an accuracy of more than 99% in tumors larger than 3 mm; however, false-negative and false-positive results may be obtained. Its risk of local spread is very small, an advantage over incisional biopsy. The most common complication is intralesional hemorrhage and hyphema.
Asunto(s)
Humanos , Femenino , Neoplasias del Iris/patología , Biopsia con Aguja Fina/normas , Iris/patologíaRESUMEN
To study the histopathological findings of the early cases of failed DSAEK grafts and to analyze the causes of graft failure. Retrospective study of 13 failed DSAEK grafts [four grafts submitted alone with no host cornea] of 12 patients. The histopathologic features are correlated with the clinical and operative findings. Significant attenuation of the endothelial cells found in 10/13 cases [77%], retained recipient Descemet's membrane in 7/13 [54%], variability of graft thickness in 5/13 [38%] and two of these had stromal irregularity. Retrocorneal fibrous membrane along the donor's Descemet's membrane was found in 4/13 [31%] resulting in endothelial detachment in one case. Eight of the nine host cornea-graft specimens were found to have: total graft-cornea detachment [in one], subtotal in four and partial [= 50% of graft length] in three. The detached flaps showed infection at the interface of the graft-host cornea in two, epithelial ingrowth and fibrous proliferation along the anterior stromal surface of the graft [one case each]. An additional histopathological finding was secondary amyloid deposition within the host stroma [in one]. Irregular or thick graft, graft-host interface fibrous/epithelial ingrowth, and infection all predispose to DSAEK failures related to graft detachment. Endothelial cells attenuation and retrocorneal fibrous membrane are major causes for primary graft failure