Embyotoxicity of norfloxacin in mice

In this investigation the embryotoxicity of norfloxacin has been studied. Oral administration of norfloxacin to pregnant female mice in the first two weeks of pregnancy of a dose of 550mg/kg/day significant decreases litter size and increases fetal resorption rate. There is no evidence of teratogenic effects. The rate of embryonic lost was also increased in treated group as compared with control