RESUMEN
Fluid resuscitation aims to maintain intravenous volume without significant effects on hemostasis. Several types of intravenous fluid are available for use in a patient who has suffered trauma, but there is evidence that some resuscitation fluids may affect primary hemostasis. The present study was designed to investigate the effects of isovolaemic haemodilution with hydroxyethyl starch [HES] and albumin 5% on thrombus formation in artificial arterial grafts. Twenty rabbits were included, the animals were subdivided into three groups as follows: group 1 [6 rabbits] received isovolaemic haemodilution with HES [10 ml /kg], group 2 [7 rabbits] received haemodilution with albumin 5% [10 ml / kg] and group 3 [7 rabbits] non-haemodiluted controls. A polytetrafluoroethylene graft [PTFE length 13mm, inner diameter 3mm] was inserted into the abdominal aorta of the rabbits. After 2 days the vessel grafts were removed and weighed. The thrombus masses were scraped from the inner surfaces and weighed separately. The studied parameters were the aortic blood flow and the amount of thrombus formation. The results showed that the blood flow increased by about 70% and 60% after haemodilution with HES and albumin, respectively, and remained high in the haemodiluted animals after insertion of the graft. Also, the amount of thrombus formation in the inner wall of the graft was reduced by haemodilution with HES. In conclusion, isovolaemic haemodilution with both HES and albumin increased blood flow in the rabbit, while haemodilution with HES also reduced the amount of thrombus formation