RESUMEN
Parkinson's Disease [PD] is a kind of motion disorders of central nervous system that is caused by degeneration of basal ganglia. Postural instability is one of the important clinical presentations of PD. The aim of present study was to determine the efficacy of balance trainings using balance simulator instrument on postural stability along with medications in this spectrum of patients. In this interventional study, thirty patients with PD and balance disturbances were selected and referred to rehabilitation ward during a 7-month period. Patients underwent 12 sessions of physical therapy programs for 4 weeks. Design of study was an interventional before-after trial. Evaluation was performed using Timed Up and Go [TUG], Berg Balance Scale questionnaire, falling risk and postural instability indices of Biodex instrument and obtained data were analyzed using t-test and wilcoxon statistical tests. The IRCT code for this study is 201212163217 N6. The mean TUG before trainings was 21.8 +/- 12.91 seconds and reached to 17.8 +/- 9.29 [s] afterward [P<0.001]. The fall risk and postural instability of 29 patients improved after interventions and deteriorated just in one case. The average of BBS before exercises was 42.6 +/- 11.16 and increased to 48.4 +/- 7.06 after intervention significantly [P<0.001]. Performing balance trainings lead to increase in walking speed, decrease in fall risk and improvement of postural stability and daily functional activities in patients with PD. Further studies for comparing the effectiveness of diverse rehabilitation treatments as well as long term follow up of patients will be necessary
RESUMEN
C-reactive protein, a well known marker of inflammation is being investigated as a probable marker of predicting acute cardiovascular events and its severity. The aim of the present study was to assess the possible role of highly-sensitivity C-reactive protein [hs-CRP] in predicting short-term functional outcome of ischemic stroke. A prospective study was conducted on subjects admitted with first attack of confirmed ischemic stroke. It included 50 male and 52 female. Serum hs-CRP was measured in the 2[nd] [CRP-D2] and 5[th] days [CRP-D5] post-stroke. Modified Rankin scale [MRS] was measured in all subjects in the 2[nd] [MRS-D2], 5[th] days [MRS-D5] and also 3 month [MRS-M3] after stroke to assess the short-term functional outcome and mortality of subjects. The mean age of the patients was 71.75 +/- 11.44 years. The mortality rate was 47.1% in the third months after stroke. There was no significant correlation between CRP-D2 and MRS-M3 and also between CRP-D5 and MRS-M3 [P>0.05]. However there was a significant association between high CRP-D2 [CRP>3] and MRS-M3 and also between high CRP-D5 and MRS-M3 [P<0.005]. This study showed that the value of CRP by itself could not predict the severity of short-term functional disability and it might not be useful as a clinical tool for predicting outcome