RESUMEN
Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease [CHD]. We sought to assess the difference in serum cytokines levels between children with and without CHD
Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants' demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, andIL-18 were measured via ELISA
Results: Mean age of the participants was 4.28 +/- 3.44, 3.12 +/- 3.87, and 3.30 +/- 3.61 years in the cyanotic, acyanotic, and control groups, respectively [p value = 0.414]. Mean values of TNF-alpha [p value < 0.001], IL-6 [p value < 0.001], IL-18 [p value = 0.030], right ventricular pressure [p value < 0.001], and pulmonary pressure [p value = 0.015] were higher in the case group, while the BMI was higher in the controls [p value < 0.001]. Mean values of TNF-alpha [p value < 0.001], IL-6 [p value < 0.001], and right ventricular pressure [p value < 0.001] were significantly higher in the cyanotic children, whereas the BMI was higher in the controls [p value < 0.001]. Levels of TNF-alpha and IL-6 had significant correlations with right ventricular pressure
Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD
RESUMEN
This study aimed to evaluate the erythromycin efficacy in childhood cyclic vomiting syndrome. Cyclic vomiting syndrome [CVS] is an unusual cause of episodic emesis in children and erythromycin is an effective treatment. In this prospective study, 301 patients with a final diagnosis of CVS enrolled in two separated groups. The first group received erythromycin for 7 days and propranolol for at least 9 months [n=155]. The second group was treated with propranolol alone for at least 9 months [n=146]. These two groups were compared for response to the treatment and the recurrence of symptoms after treatment completion. Relationship of response, recurrence, and characteristics of the disease was assessed. Both groups showed a significant difference in terms of response to treatment [P=0.002], however the recurrence after treatment completion had no considerable difference [P=0.563]. There was no relationship between CVS characteristics and these two items [response and recurrence]. In our point of view, the addition of erythromycin to standard propranolol treatment can improve the response to treatment, although it has no significant effect on recurrence of CVS symptoms. We suggest the use of erythromycin for 7 days in addition to CVS standard therapy
RESUMEN
Due to the increased prevalence of celiac disease in chromosomal anomalies and other congenital anomalies, this study was conducted to evaluate the seroprevalence of celiac disease [CD] in patients with congenital heart defects [CHD]. This case-control study was done on 1002 children in two groups of CHD patients [n=402] and controls [n=600]. The serum tissue transglutamianse [TTG] levels were investigated. The two groups were compared in terms of TTG IgA levels and p<0.05 was considered as the significant level. The means of serum TTG IgA levels in children with CHD and the control groups were 19.17 +/- 46.67 and 7.77 +/- 10.02 u/mL respectively [p=0.001]. After ANOVA analysis a significant difference between two cyanotic and acyanotic subgroups of cases and control groups was observed [p=0.000]. The follow up tukey test showed only non-significant difference between the cyanotic and acyanotic cases. The frequency of TTG IgA with the consideration of 20 u/mL as cut-off point showed a significant association with groups [X2=28.31 and p=0.000]. According to the results the serum TTG IgA levels were significantly higher in patients with CHD than normal children and screening for CD in children with CHD is recommended