Mass spectrometry in clinical laboratory: applications and future prospects

Innovations in laboratory medicine face additional challenges due to the unmet need for extremely precise methods of disease diagnosis. Developments in mass spectrometry-based disease biomarker identification are constantly expanding the field of clinical diagnosis. More mass spectrometry-based in vitro diagnostics are anticipated to move from the bench to the bedside shortly, although several are currently incorporated into standard clinical procedures. The molecular detection by mass spectrometry technique is very effective in diagnosis of the disease and therapeutic monitoring because of its extremely high sensitivity, specificity, and short turnaround time. Mass spectrometry is a potent analytical instrument that may be used to analyse a variety of materials and matrices; its use in clinical laboratory medicine applications is rising. For clinical prognostics and diagnostic purposes, mass spectrometry imaging has been widely utilized to distinguish between healthy and diseased tissues. Modern single-cell studies will benefit from its cutting-edge applications, which will offer comprehensive cellular biochemical data for mechanistic comprehension and, eventually, the development of therapeutic interventions. Within the field of laboratory medicine, the application of mass spectrometry is crucial, especially in terms of diagnostics and therapeutic drug monitoring. This review on the clinical application of mass spectrometry and its future prospects promises an insightful exploration of the evolving landscape of mass spectrometry in clinical settings, delving into its current applications and shedding light on its potential future advancements, for which a comprehensive search in the PubMed, ScienceDirect, and Web of Science databases was conducted.

Irritable bowel syndrome: classification, dietary approach, pharmacological and psychological treatments

Irritable bowel syndrome is a long-lasting disorder that affects a significant number of people worldwide. This comprehensive study explores the complexities of IBS, thoroughly investigating its classification, signs, and various treatment approaches. It emphasizes the nature of IBS symptoms, highlighting the importance of tailored treatment strategies that consider adjustments, medications, and psychological therapies. The study recognizes that each patient responds differently to treatments, underscoring the need for care. By shedding light on the nature of IBS and acknowledging experiences, this research aims to provide an updated and evidence-based understanding of managing IBS. The significance of an approach is emphasized, recognizing how health, psychological well-being, and lifestyle factors are interconnected in IBS. Alongside medication for symptom relief and therapies addressing aspects, dietary modifications play a vital role in improving patient outcomes and overall quality of life. This integrated strategy aims to address IBS's impact on health and overall well-being. In summary, this study provides information for healthcare professionals and researchers to provide an understanding of the complexities of IBS and advocate for a personalized and evidence-based approach to its treatment.