value of uterine artery doppler in assessment of development of pre-eclampsia in women at risk

To evaluate the role of Doppler study done in the second trimester of pregnancy in the prediction of pre eclampsia. Prospective clinical trial. Department of Obstetrics and Gynecology, Kasr El-Aini Hospital. One hundred pregnant women with singleton gestation, in the second trimester, at risk of pre-eclampsia were subjected to Doppler ultrasound at 18-26 wks to measure S/D ratio, Resistance index RI, Pulsatility index of the uterine artery PI, in addition to the presence or absence of a diastolic notch. All women were followed up till delivery. There were significant differences between patients who developed PIH [eleven cases] and those who didn't develop as regards Doppler parameters at mid trimester including PI. RI, S/D ratio and the presence of diastolic notch. Doppler ultrasound at midtrimester identifies group of women at high risk for the subsequent development of pre-eclampsia for whom we can start preventive regimens

Subclinical hyperthyroidism as a potential factor for dysfunctional uterine bleeding

To evaluate the functional status of thyroid gland in apparently euthyroid women with dysfunctional uterine bleeding. Forty apparently euthyroid women with menorrhagia and no pathologic lesion in the genital tract were compared to 20 women having normal menstrual cycle as control group. All women were subjected to hormonal assay: total and free T3, T4 and TSH, Serum PRL, P [progesterone], total and free testosterone. A statistically significant difference in the values of TSH, total T3, free T3 and total T4 in the menorrhagia group compared to the control group. Prolactin was decreased significantly in the menorrhagia group. Subclinical hyperthyroidism can be a potential risk factor for dysfunctional uterine bleeding. Other studies are needed to confirm our findings

Interleukin-8 compared to fetal fibronectin for prediction of preterm labor in women with twin pregnancy: a prospective cross sectional study

To investigate the value of measuring IL-8 compared to Fetal Fibronectin [FFN] for predicting preterm labor in twin pregnancy. Prospective controlled trial. Thirty twin pregnant women between 28-34 weeks gestation not in labor were compared to thirty twin pregnancy women having preterm labor. Cervicovaginal fluid was collected from all cases for detection of Fetal fibronectin and Interleukin-8. IL-8 level at a cut off value of 1500pg/ml had a sensitivity 93.3%, a specificity 96.7%, a positive predictive value 96.6% and a negative predictive value 93.3%. These Figures were better than FFN level which had a sensitivity 90.0%, a specificity 86.7%, a positive predictive value 87.1% and a negative predictive value 89.7% in diagnosis of patients with premature labor. In twin pregnancies a biochemical markers such as fetal fibronectin and interleukin-8 could be considered a useful tool in clinical practice for early identification of women at risk of preterm labor