Light microscopic study of the effect of flubendazole, praziquantel and combination of both drugs on adult schistosoma mansoni [with 14 figures]

It is considered that combination of chemotherapy with other control measures can reduce transmission and morbidity of schistosomiasis. This study was done using 60 albino mice infected with cercariae of Schistosoma mansoni. Mice were divided into 4 groups [control, flubendazole treated, praziquantel treated and combination of both drugs]. The effect of treatment was evaluated on male and female worms after [1, 2 and 3 Week Post Treatment]. Worms were collected by perfusion of portal vein and mesenteric veins separately, stained with acetic acid alum carmine and examined by light microscope

Scanning electron microscopy of adult schistosoma mansoni after treatment with praziquantel, flubendazol and combination of both [with 4 plates]

Many antischistosomal drugs are known to cause changes in the ultrastructure of adult worms. This study was done using 60 albino mice infected with cercariae of Schistosoma mansoni. Mice were divided into 4 groups [Control, Flubendazole-treated, Praziquantel-treated and the last group treated by combination of both drugs]. The effect of treatment was evaluated on male and female worms after one and three weeks post treatment. Worms were collected by perfusion of portal vein and mesenteric vein separately then examined by scanning electron microscopy