Differential preservation of rabbit kidney and liver tissue in ringer lactate, euro collins and university of wisconsin solutions

Formalin, the most widely used preservative, has certain drawbacks. The foremost of them is interference with immunohistochemistry. To evaluate the efficacy of three commonly used organ preservation solutions for tissue preservation this experimental study was carried out on rabbit kidney and liver The tissue slices were stored in Ringer Lactate, Euro Collins awl University of Wisconsin solutions [UW solution], for various fixed time intervals. The three solutions were used in their original form as well as with addition of antimicrobial agents. Morphological preservation was assessed by a semi quantitative method. Kidney slices showed better morphological preservation than liver tissue. UW solution demonstrated the highest preservation of the three solutions tried. UW solution was especially effective for liver preservation. Addition of anti microbial agents was more beneficial to kidney preservation than liver. Thus it was concluded that organ preservation solutions may be used for tissue preservation as well

Primary carcinoid of the urinary baldder

The occurrence of a primary carcinoid tumour of the urinary bladder is extremely rare. The case of a 35 year-old male with carcinoid tumour arising in the urinary bladder is presented. Transurethral resection of a polypoid small tumour [1.0 cm in diameter] was performed. Immunohistochemical study using neuroendocrine markers allowed a straightforward diagnosis of a low-grade neuroendocrine tumour [carcinoid tumour] of the urinary bladder to be made. This tumour shows specific clinical, gross and histological features and should be considered in the differential diagnosis of bladder neoplasms

Morphological variations in appendicectomy specimens

To study and describe the various gross and microscopic presentations of appendicectomy specimens. Prospective analysis of surgical specimens. Pathology Department, PGMI, Lahore. Single center. Morphological examination of the specimens. 250 appendicectomy specimens were studied. The gender more frequently affected was male [1.6:1 cases]. The mean age was 16 years. The clinical diagnosis was acute appendicitis in 246 cases. This was confirmed in 209 cases. 28 cases revealed normal morphology. Worm infestation was seen in 4 cases. All of these belonged to the paediatric age group. One case revealed a carcinoid tumour. All resected specimens including appendices should be subjected to a thorough histopathological examination