Non-Secretion of blood group antigens and susceptibility to urinary tract infection

The material of the present study comprised 103 patients of urinary tract infection confirmed by bacterial examination of urine, [64] out of them had chronic renal failure, due to recurrent urinary tract infection these patients underwent determination of blood group [ABO and Lewis] and secretor status, to find out if there is relation between it and susceptibility to urinary tract infection. There was a predominance of blood group AB and non secretor status [Se Se] which proves that the absence of A and B antibodies and also absence of Se gene combine to give an increased risk to urinary tract infection. The appearance of increased frequency of Lea [a-b] in non secretors confirms the consumption of Le antigen as receptors for pathogenic organisms.There is no predominance of special blood groups in patients not confirmed to be recurrent

Influence of ABO and Lewis blood group and secretor status on susceptibility to throat infection and rheumatic fever

Ninty patients with throat infection and 25 with rheumatic fever [as a sequelae of streptococcal infection] underwent determination of blood groups [ABO, Lewis] and secretor status to find their susceptibity to throat infection. There was no predominance of a special blood group in throat infection subgroup, while secretion of blood group substances has its effects on the pathogenic organisms more than the normal flora. The genetic control has a rate, the homozygous non secretors [Se/se] and heterozygous secretors [Se/se] are more susceptible than the homozygous secretors [Se/se] and the appearance of increased frequency of Le [a-b-] in patients especially non secretors who have perhaps inherited le gene, suggests that le a antigen was consumed as receptor for pathogen

Blood groups, secretor status and role of Lewis in adenovirus conjuncitivitis

40 patients of adenovirus conjunctivitis were diagnosed by clinical picture, absence of evidence for bacterial infection and confirmed by serological CFT. Their blood grouping [ABO and Lewis] and aecretor status were determined to find association of adenovirus confunctivitis with genetic composition of blood groups and secretor genes. In AB blood group there is insignificant increase which may be attributed to absence of corresponding anti-A and anti-B. In homozygous nonsecretors [se/se] there is highly significant increase of blood group Le[a+b-] who have perhaps Le [a+b-] phenotype, as Le[a] antigen is consumed as receptors for the adenovirus